promoting access to White Rose research
نویسندگان
چکیده
Background: Insulin-like growth factor (IGF)-1 has been implicated in the pathogenesis of Alzheimer’s disease (AD). Methods: We compared the level of circulating total and bioavailable IGF-1, by simultaneous measurements of IGF-1 and IGF binding protein (IGFBP)-3, between 87 patients diagnosed with AD and 126 age and sex matched control subjects without cognitive impairment. Blood samples were collected and IGF-1 and IGFBP-3 measured by ELISA. Subjects were also genotyped for apolipoprotein E. Results: Total circulating IGF-1 levels were significantly raised in the AD group as compared to the control group (p=0.022). There was no significant difference in the circulating level of IGFBP-3 between the two groups. When the IGF-1 levels were ratioed against IGFBP-3 levels as an indicator of unbound, bioavailable circulating IGF-1, there was a significant increase in the molar IGF-1:IGFBP-3 ratio in the AD subjects (0.181 ± 0.006) as compared to the controls (0.156 ± 0.004) (p<0.001). Logistic regression analysis revealed that an increase in the IGF-1:IGFBP-3 molar ratio increased the risk of AD significantly. Conclusion: The results of increased total and free circulating IGF-1 support the hypothesis that in its early stages late-onset AD reflects a state of resistance to IGF-1.
منابع مشابه
Antioxidative Properties and Toxicity of White Rose Extract
Background: Rosa damascena is a traditional medicinal plant used in Asia to treat several ailments. This study reports In vitro and In vivo antioxidative properties and toxicity of methanolic and aqueous extracts of white rose, an indigenous variety of Rosa damascena from Iran. Methods: The antimicrobial activities, total phenolics, antioxidative properties and the blood sera Ferric-Reducin...
متن کاملPromoting Access to White Rose Research Papers Navigation: Am I Really Lost or Virtually There?
Data is presented from virtual environment (VE) navigation studies that used buildingand chessboard-type layouts. Participants learned by repeated navigation, spending several hours in each environment. While some participants quickly learned to navigate efficiently, others remained almost totally disoriented. In the virtual buildings this disorientation was illustrated by mean direction estima...
متن کاملWhite Rose Grid Portals: Practice and Experience
This paper reports our experience gained with the development of portals for the White Rose Grid user community over the last three years. During this period we have studied and applied a variety of technologies in an effort to improve access to the White Rose Grid resources from the user’s desktop. Such technologies include the Sun Grid Engine Portal, Grid Portal Development Kit software, Stru...
متن کاملPredicting Cut Rose Stages of Development and Leaf Color Variations by Means of Image Analysis Technique
The monitor and prediction of crop developmental stages, particularly harvest time, play an important role in planning greenhouse cropping programs and timetables by cut rose producers. There have been many scientific reports on the application of image analysis technology in estimating greenhouse crop growth stages. In the present research, we studied leaf color variations over time by taking ...
متن کامل